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Emerging nanomaterials for immune modulation

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Emerging nanomaterials for immune modulation

Guest Editors: Lang Rao (Shenzhen Bay Laboratory, China), Jianxun Ding (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China), and Chao Wang (Soochow University, China).

 presents a collection on Emerging nanomaterials for immune modulation.

William B. Coley first reported in 1891 that bacterial toxins could be used as an immunotherapy to treat patients with bone and soft- tissue sarcoma. After a century of research, cancer immunotherapy has revolutionized oncology and offers new treatment options for many types of cancer. Owing to the clinical success of immune checkpoint blockers, immunotherapy has now been established as a new pillar of cancer treatment. Despite much promise, the majority of patients do not benefit from the currently available immunotherapies and many develop immune-related adverse events.

Recent advances in materials science and nanotechnology have offered many further opportunities for immunotherapy. A variety of nanomaterials including lipid, polymer, silicon, gold, iron oxide nanoparticles and different forms of cell-derived extracellular vesicles have been engineered to elicit potent immune responses and achieve controllable immune modulation. This field is in its infancy and much work remains, with nanomaterials holding significant potential to advance both fundamental and applied immunology.

This collection aims at better understanding the role and use of nanomaterials for immune modulation and will comprise a selection of original research papers and reviews focusing on emerging immunomodulatory nanomaterials.

The subjects include, but are not limited to:

  • Nanomaterials in immune modulation
  • Nanomaterials in vaccine design including adjuvants or for antigen delivery
  • Nanomaterials for delivery of immunomodulatory drugs/compounds
  • Nanomaterials for tracking immune cells or imaging cell-based therapies
  • Nanomaterial-related immunotoxicity

This collection is now closed to new submissions.

  1. Immunotherapy has gradually emerged as the most promising anticancer therapy. In addition to conventional anti-PD-1/PD-L1 therapy, anti-CTLA-4 therapy, CAR-T therapy, etc., immunotherapy can also be induced by...

    Authors: Yinan Ding, Luhong Wang, Han Li, Fengqin Miao, Zhiyuan Zhang, Chunmei Hu, Weiping Yu, Qiusha Tang and Guoliang Shao
    Citation: Journal of Nanobiotechnology 2022 20:214
    Content type: Review Published on:

  2. Pancreatic ductal adenocarcinoma (PDAC) interacts closely with the tumor microenvironment (TME). The TME is remodeled by crosstalk between pancreatic cancer cells and stromal cells, and is critical for cancer ...

    Authors: Ying Li, Wenjing Zhao, Yanli Wang, Haiyan Wang and Shanglong Liu
    Citation: Journal of Nanobiotechnology 2022 20:208
    Content type: Review Published on:

  3. By 2050, the world population will increase to 10 billion which urged global demand for food production to double. Plant disease and land drought will make the situation more dire, and safer and environment-fr...

    Authors: Jianfeng Du, Baoyou Liu, Tianfeng Zhao, Xinning Xu, Han Lin, Yatai Ji, Yue Li, Zhiwei Li, Chongchong Lu, Pengan Li, Haipeng Zhao, Yang Li, Ziyi Yin and Xinhua Ding
    Citation: Journal of Nanobiotechnology 2022 20:197
    Content type: Research Published on:

  4. Psoriasis is a chronic relapsing immunological skin disease characterized by multiple cross-talk inflammatory circuits which are relevantly associated with abnormal cross-reactivity between immune cells and ke...

    Authors: Jiangmei Xu, Hao Chen, Zhaoyou Chu, Zhu Li, Benjin Chen, Jianan Sun, Wei Lai, Yan Ma, Yulong He, Haisheng Qian, Fei Wang and Yunsheng Xu
    Citation: Journal of Nanobiotechnology 2022 20:155
    Content type: Research Published on:

  5. Nanoparticle (NP) is an emerging tool applied in the biomedical field. With combination of different materials and adjustment of their physical and chemical properties, nanoparticles can have diverse effects o...

    Authors: Jin Liu, Zeyang Liu, Yan Pang and Huifang Zhou
    Citation: Journal of Nanobiotechnology 2022 20:127
    Content type: Review Published on:

  6. Immune checkpoint inhibitor-mediated immunotherapy cannot be carried out on a large scale clinically due to its low universality. In recent years, cyclic guanosine monophosphate synthase/interferon gene stimul...

    Authors: Qian Li, Qiubing Chen, Xue Yang, Yuelan Zhang, Linyue Lv, Zhuyou Zhang, Shaowei Zeng, Jiaxi Lv, Sijin Liu and Bishi Fu
    Citation: Journal of Nanobiotechnology 2022 20:84
    Content type: Research Published on:

  7. Femoral stem of titanium alloy has been widely used for hip arthroplasty with considerable efficacy; however, the application of this implant in patients with osteoporosis is limited due to excessive bone reso...

    Authors: Wei Wang, Yinze Xiong, Renliang Zhao, Xiang Li and Weitao Jia
    Citation: Journal of Nanobiotechnology 2022 20:68
    Content type: Research Published on:

  8. Stem cell-derived exosomes have recently been regarded as potential drugs for treating spinal cord injury (SCI) by reducing reactive oxygen species (ROS) and suppressing M1 macrophage polarization. However, th...

    Authors: Chao Liu, Fanqi Hu, Genlong Jiao, Yue Guo, Pan Zhou, Yuning Zhang, Zhen Zhang, Jing Yi, Yonggang You, Zhizhong Li, Hua Wang and Xuesong Zhang
    Citation: Journal of Nanobiotechnology 2022 20:65
    Content type: Research Published on:

  9. Photoimmunotherapy is one of the most promising strategies in tumor immunotherapies, but targeted delivery of photosensitizers and adjuvants to tumors remains a major challenge. Here, as a proof of concept, we...

    Authors: Hu Chen, Pengfei Zhang, Yesi Shi, Chao Liu, Qianqian Zhou, Yun Zeng, Hongwei Cheng, Qixuan Dai, Xing Gao, Xiaoyong Wang and Gang Liu
    Citation: Journal of Nanobiotechnology 2022 20:61
    Content type: Research Published on:

  10. Lymphatic system is identified the second vascular system after the blood circulation in mammalian species, however the research on lymphatic system has long been hampered by the lack of comprehensive imaging ...

    Authors: Shaolong Qi, Xinyu Wang, Kun Chang, Wenbin Shen, Guocan Yu and Jianshi Du
    Citation: Journal of Nanobiotechnology 2022 20:24
    Content type: Review Published on:

  11. Regulation of stimulator of interferon genes (STING) pathway using agonists can boost antitumor immunity for cancer treatment, while the rapid plasma clearance, limited membrane permeability, and inefficient c...

    Authors: Meixiao Zhan, Xiangrong Yu, Wei Zhao, Yongjun Peng, Shaojun Peng, Jingchao Li and Ligong Lu
    Citation: Journal of Nanobiotechnology 2022 20:23
    Content type: Research Published on:

  12. High doses of radiation can cause serious side effects and efficient radiosensitizers are urgently needed. To overcome this problem, we developed a biomimetic nanozyme system (CF) by coating pyrite (FeS2) into tu...

    Authors: Chunyu Huang, Zeming Liu, Mingzhu Chen, Liang Du, Chunping Liu, Shuntao Wang, Yongfa Zheng and Wei Liu
    Citation: Journal of Nanobiotechnology 2021 19:457
    Content type: Research Published on:

  13. The complex tumor microenvironment and non-targeting drugs limit the efficacy of clinical tumor therapy. For ensuring the accurate delivery and maximal effects of anticancer drugs, it is important to develop i...

    Authors: Xiaoli Zhang, Yi Lu, Die Jia, Wei Qiu, Xianbin Ma, Xingliang Zhang, Zhigang Xu and Feiqiu Wen
    Citation: Journal of Nanobiotechnology 2021 19:455
    Content type: Research Published on:

  14. Mono-therapeutic modality has limitations in combating metastatic lesions with complications. Although emerging immunotherapy exhibits preliminary success, solid tumors are usually immunosuppressive, leading t...

    Authors: Qiaoqi Chen, Liang Zhang, Lin Li, Mixiao Tan, Weiwei Liu, Shuling Liu, Zhuoyan Xie, Wei Zhang, Zhigang Wang, Yang Cao, Tingting Shang and Haitao Ran
    Citation: Journal of Nanobiotechnology 2021 19:449
    Content type: Research Published on:

  15. The construction of a nanoimmune controlled-release system that spatiotemporally recognizes tumor lesions and stimulates the immune system response step by step is one of the most potent cancer treatment strat...

    Authors: Haitao Sun, Tianzhu Yu, Xin Li, Yangyang Lei, Jianke Li, Xiuhui Wang, Peike Peng, Dalong Ni, Xiaolin Wang and Yu Luo
    Citation: Journal of Nanobiotechnology 2021 19:433
    Content type: Research Published on:

  16. Lactate plays a critical role in tumorigenesis, invasion and metastasis. Exhausting lactate in tumors holds great promise for the reversal of the immunosuppressive tumor microenvironment (TME). Herein, we repo...

    Authors: Ruiqing He, Jie Zang, Yuge Zhao, Ying Liu, Shuangrong Ruan, Xiao Zheng, Gaowei Chong, Dailin Xu, Yan Yang, Yushan Yang, Tingting Zhang, Jingjing Gu, Haiqing Dong and Yongyong Li
    Citation: Journal of Nanobiotechnology 2021 19:426
    Content type: Research Published on:

  17. Combining radiotherapy with PD1 blockade has had impressive antitumor effects in preclinical models of metastatic lung cancer, although anti-PD1 resistance remains problematic. Here, we report results from a t...

    Authors: Yun Hu, Sébastien Paris, Hampartsoum Barsoumian, Chike O. Abana, Kewen He, Duygu Sezen, Mark Wasley, Fatemeh Masrorpour, Dawei Chen, Liangpeng Yang, Joe D. Dunn, Saumil Gandhi, Quynh-Nhu Nguyen, Maria Angelica Cortez and James W. Welsh
    Citation: Journal of Nanobiotechnology 2021 19:416
    Content type: Research Published on:

  18. With the in-depth exploration on cancer therapeutic nanovaccines, increasing evidence shows that the poor delivery of nanovaccines to lymphoid organs has become the culprit limiting the rapid induction of anti...

    Authors: Ting Cai, Huina Liu, Shun Zhang, Jing Hu and Lingxiao Zhang
    Citation: Journal of Nanobiotechnology 2021 19:389
    Content type: Review Published on:

  19. Matrix metalloproteinase (MMP) 2 and 9 are the family members of proteases normally up-regulated in tumor to enhance the invasion and metastatic of tumor cells, and are associated with poor outcome of head and...

    Authors: Lin-Lin Bu, Han-Qi Wang, Yuanwei Pan, Lei Chen, Hao Wu, Xianjia Wu, Chenchen Zhao, Lang Rao, Bing Liu and Zhi-Jun Sun
    Citation: Journal of Nanobiotechnology 2021 19:379
    Content type: Research Published on:

  20. Cytosine-phosphate-guanine (CpG) dinucleotides has been used as adjuvants for cancer immunotherapy. However, unmodified CpG are not very efficient in clinical trials. Glucose, ligand of C-type lectin receptors...

    Authors: Xiaojing Xu, Minfeng Gan, Youzhen Ge, Cheng Yi, Tianyun Feng, Mengjie Liu, Cenhao Wu, Xiang Chen, Weidong Zhang, Lixiang Zhao and Jun Zou
    Citation: Journal of Nanobiotechnology 2021 19:376
    Content type: Research Published on:

  21. Mild-temperature photothermal therapy (mild-PTT) has emerged as a highly promising antitumor strategy by triggering immunogenic cell death (ICD) to elicit both innate and adaptive immune responses for tumor co...

    Authors: Zaigang Zhou, Ning Jiang, Jiashe Chen, Chunjuan Zheng, Yuanyuan Guo, Ruirong Ye, Ruogu Qi and Jianliang Shen
    Citation: Journal of Nanobiotechnology 2021 19:375
    Content type: Research Published on:

  22. Hepatocellular carcinoma (HCC) is a common malignant tumor with high rate of metastasis and recurrence. Although immune checkpoint blockade (ICB) has emerged as a promising type of immunotherapy in advanced HC...

    Authors: Jianjun Xu, Qichang Zheng, Xiang Cheng, Shaobo Hu, Chen Zhang, Xing Zhou, Ping Sun, Weimin Wang, Zhe Su, Tianhao Zou, Zifang Song, Yun Xia, Xiaoqing Yi and Yang Gao
    Citation: Journal of Nanobiotechnology 2021 19:355
    Content type: Research Published on: