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Constructing 'intelligent' microbial cell factories

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This special issue of covers the topic of 'Constructing 'intelligent' microbial cell factories' by dynamic and systems metabolic engineering approaches.

Edited by Prof Long Liu, Jiangnan University, China

  1. In industrial fermentation, pH fluctuation resulted from microbial metabolism influences the strain performance and the final production. The common way to control pH is adding acid or alkali after probe detec...

    Authors: Chenyi Li, Xiaopeng Gao, Xiao Peng, Jinlin Li, Wenxin Bai, Jiadong Zhong, Mengchao He, Ke Xu, Ying Wang and Chun Li
    Citation: Microbial Cell Factories 2020 19:202
    Content type: Research Published on:

  2. Cinnamyl alcohol is not only a kind of flavoring agent and fragrance, but also a versatile chemical applied in the production of various compounds. At present, the preparation of cinnamyl alcohol depends on pl...

    Authors: Chen Zhang, Qian Xu, Hongliang Hou, Jiawei Wu, Zhaojuan Zheng and Jia Ouyang
    Citation: Microbial Cell Factories 2020 19:163
    Content type: Research Published on:

  3. Escherichia coli BL21 is arguably the most popular host for industrial production of proteins, and industrial fermentations are often plagued by phage infections. The CRISPR/Cas system is guided by a gRNA to clea...

    Authors: Li Liu, Dongdong Zhao, Lijun Ye, Tao Zhan, Bin Xiong, Muzi Hu, Changhao Bi and Xueli Zhang
    Citation: Microbial Cell Factories 2020 19:136
    Content type: Research Published on:

  4. Genome streamlining is a feasible strategy for constructing an optimum microbial chassis for synthetic biology applications. Genomic islands (GIs) are usually regarded as foreign DNA sequences, which can be ob...

    Authors: Peixin Liang, Yiting Zhang, Bo Xu, Yuxin Zhao, Xiangsheng Liu, Weixia Gao, Ting Ma, Chao Yang, Shufang Wang and Ruihua Liu
    Citation: Microbial Cell Factories 2020 19:70
    Content type: Research Published on:

  5. Bacillus licheniformis 2709 is extensively applied as a host for the high-level production of heterologous proteins, but Bacillus cells often possess unfavorable wild-type properties, such as production of viscou...

    Authors: Cuixia Zhou, Huiying Zhou, Dengke Li, Huitu Zhang, Hongbin Wang and Fuping Lu
    Citation: Microbial Cell Factories 2020 19:45
    Content type: Research Published on:

  6. Microbial cell factories are widely used in the production of acidic products such as organic acids and amino acids. However, the metabolic activity of microbial cells and their production efficiency are sever...

    Authors: Zhengming Zhu, Jinhua Yang, Peishan Yang, Zhimeng Wu, Juan Zhang and Guocheng Du
    Citation: Microbial Cell Factories 2019 18:136
    Content type: Research Published on:

  7. Heparosan is the unsulfated precursor of heparin and heparan sulfate and its synthesis is typically the first step in the production of bioengineered heparin. In addition to its utility as the starting materia...

    Authors: Asher Williams, Kamil S. Gedeon, Deepika Vaidyanathan, Yanlei Yu, Cynthia H. Collins, Jonathan S. Dordick, Robert J. Linhardt and Mattheos A. G. Koffas
    Citation: Microbial Cell Factories 2019 18:132
    Content type: Research Published on:

  8. Many fermented foods and beverages are produced through the action of complex microbial communities. Synthetic biology approaches offer the ability to genetically engineer these communities to improve the prop...

    Authors: Rachatida Det-udom, Charlie Gilbert, Long Liu, Cheunjit Prakitchaiwattana, Tom Ellis and Rodrigo Ledesma-Amaro
    Citation: Microbial Cell Factories 2019 18:101
    Content type: Research Published on:

  9. Microorganisms have long been used as chemical plant to convert simple substrates into complex molecules. Various metabolic pathways have been optimised over the past few decades, but the progresses were limit...

    Authors: Zheng Lin Tan, Xiang Zheng, Yinan Wu, Xingjin Jian, Xinhui Xing and Chong Zhang
    Citation: Microbial Cell Factories 2019 18:82
    Content type: Review Published on:

  10. Non-conventional yeasts are playing important roles as cell factories for bioproduction of biofuels, food additives and proteins with outstanding natural characteristics. However, the precise genome editing is...

    Authors: Peng Cai, Jiaoqi Gao and Yongjin Zhou
    Citation: Microbial Cell Factories 2019 18:63
    Content type: Review Published on:

  11. Nature has evolved exquisite sensing mechanisms to detect cellular and environmental signals surrounding living organisms. These biosensors have been widely used to sense small molecules, detect environmental ...

    Authors: Xia Wan, Monireh Marsafari and Peng Xu
    Citation: Microbial Cell Factories 2019 18:61
    Content type: Review Published on:

  12. Naturally occurring carotenoids have been isolated and used as colorants, antioxidants, nutrients, etc. in many fields. There is an ever-growing demand for carotenoids production. To comfort this, microbial pr...

    Authors: Chonglong Wang, Shuli Zhao, Xixi Shao, Ji-Bin Park, Seong-Hee Jeong, Hyo-Jin Park, Won-Ju Kwak, Gongyuan Wei and Seon-Won Kim
    Citation: Microbial Cell Factories 2019 18:55
    Content type: Review Published on:

  13. Metabolic engineering allows for the rewiring of basic metabolism to overproduce both native and non-native metabolites. Among these biomolecules, nutraceuticals have received considerable interest due to thei...

    Authors: Shuo-Fu Yuan and Hal S. Alper
    Citation: Microbial Cell Factories 2019 18:46
    Content type: Review Published on:

  14. Metabolic engineering has been enabling development of high performance microbial strains for the efficient production of natural and non-natural compounds from renewable non-food biomass. Even though microbia...

    Authors: Damla Huccetogullari, Zi Wei Luo and Sang Yup Lee
    Citation: Microbial Cell Factories 2019 18:41
    Content type: Review Published on:

  15. Streptomyces chattanoogensis L10 is the industrial producer of natamycin and has been proved a highly efficient host for diverse natural products. It has an enormous potential to be developed as a versatile cell ...

    Authors: Qing-Ting Bu, Pin Yu, Jue Wang, Zi-Yue Li, Xin-Ai Chen, Xu-Ming Mao and Yong-Quan Li
    Citation: Microbial Cell Factories 2019 18:16
    Content type: RESEARCH Published on:

  16. The shortage of food based feedstocks has been one of the stumbling blocks in industrial biomanufacturing. The acetone bioproduction from the traditional acetone–butanol–ethanol fermentation is limited by the ...

    Authors: Hao Yang, Bing Huang, Ningyu Lai, Yang Gu, Zhimin Li, Qin Ye and Hui Wu
    Citation: Microbial Cell Factories 2019 18:6
    Content type: RESEARCH Published on:

  17. Glucosamine-6-phosphate N-acetyltransferase (GNA1) is the key enzyme that causes overproduction of N-acetylglucosamine in Bacillus subtilis. Previously, we increased GlcNAc production by promoting the expression ...

    Authors: Wenlong Ma, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du and Long Liu
    Citation: Microbial Cell Factories 2019 18:1
    Content type: RESEARCH Published on: